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Publications (since 2015)



Total citations (updated June, 2020) : 47751

1. Iozzo, R.V., Schaefer, L. Proteoglycan form and function: A comprehensive nomenclature of proteoglycans. Matrix Biol. 42:11-55, 2015. PMID:25701227

2. Borges, M.C., Narayanan, V., Iozzo, R.V., Ludwig, M.S. Deficiency of decorin induces expression of Foxp3 in CD4+-CD25+-T cells in a murine model of allergic asthma. Respirology. 20:904-911, 2015. PMID: 25712878

3. Theocharis, A.D., Skandalis, S., Neill, T., Multhaupt, H.A., Hubo, M., Frey, H., Gopal, S., Gomes, A., Afratis, N., Lim, H.C., Couchman, J.R., Filmus, J., Ralph, D.S., Schaefer, L., Iozzo, R.V., Karamanos, N.K. Insights into the key roles of proteoglycans in breast cancer biology and translational medicine. Biochim. Biophys. Acta. 1855:276-300, 2015. PMID:25829250

4. Gordon, J.A., Freedman, B.R., Zuskov, A., Iozzo, R.V., Birk, D.E., Soslowsky, L.J. Achilles tendons from decorin- and biglycan-null mouse models have inferior mechanical and structural properties predicted by an image-based empirical damage model. J. Biomech. S0021-9290:00150-00155, 2015. PMID:25888014

5. de Miranda de Araujo, L.B., Horgan, C.E., Aron, A., Iozzo, R.V., Lechner, B.E. Compensatory fetal membrane mechanisms between biglycan and decorin in inflammation. Mol. Reprod. Dev. 82:387-396, 2015. PMID:25914258

6. Fedele, C., Singh, A., Zerlanko, B.J., Iozzo R.V., Languino LR. The αvβ6 integrin is transferred intercellularly via exosomes. J. Biol. Chem. 290:4545-4551, 2015. PMID:25568317 PMCID:PMC4335196

7. Morcavallo, A., Stefenallo, M., Iozzo, R.V., Belfiore, A., Morrione, A. Ligand-mediated endocytosis and trafficking of the insulin-like growth factor receptor I and insulin receptor modulate receptor function. Front. Endocrinol. 5:220, 2014. PMID:25566192

8. Tanimoto, R., Morcavallo, A., Terracciano, M., Xu, S.Q., Stefanello, M., Buraschi, S., Lu, K.G., Bagley, D.H., Gomella, L.G., Scotlandi, K., Belfiore, A., Iozzo, R.V., Morrione, A. Sortilin regulates progranulin action in castration-resistant prostate cancer cells. Endocrinology. 156:58-70, 2015. PMID:25365768

9. Xu, S.Q., Buraschi, S., Morcavallo, A., Genua, M., Shirao, T., Peiper, S.C., Gomella, L.G., Birbe, R., Belfiore, A., Iozzo, R.V.*, Morrione, A. A novel role for drebrin in regulating progranulin bioactivity in bladder cancer. Oncotarget. 6:10825-39, 2015. PMID:25839164

10. Malaguarnera, R., Nicolosi, M.L., Sacco, A., Morcavallo, A., Vella, V., Voci, C., Spatuzza, M., Xu S.Q., Iozzo, R.V., Vigneri, R., Morrione, A., Belfiore, A. Novel cross talk between IGF-IR and DDR1 regulates IGF-IR trafficking, signaling, and biological responses. Oncotarget. 6:16084-105, 2015. PMID:25840417

11. Neill, T., Schaefer, L., Iozzo, R.V. Decoding the Matrix: Instructive Roles of Proteoglycan Receptors. Biochemistry. 54:4583-4598, 2015. PMID:26177309

12. Douglass, S., Goyal, A., Iozzo, R.V. The role of perlecan and endorepellin in the control of tumor angiogenesis and endothelial cell autophagy. Connect. Tissue Res. 19:1-11, 2015. PMID:26181327

13. Gubbiotti, M.A., Neill, T., Frey, H., Schaefer, L., Iozzo, R.V. Decorin is an autophagy-inducible proteoglycan and is required for proper in vivo autophagy. Matrix Biol. 48:14-25. 2015. PMID:26344480

14. Gubbiotti, M.A., Iozzo, R.V. Proteoglycans regulate autophagy via outside-in signaling: an emerging new concept. Matrix Biol. 48:6-13. 2015. PMID: 26462577

15. Yang Y., Xu, W., Neill, T., Hu, Z., Wang, C.H., Xiao, X., Stock, S.R., Guise, T., Yun, C.O., Brendler, C.B., Iozzo, R.V., Seth, P. Systemic Delivery of an Oncolytic Adenovirus Expressing Decorin for the Treatment of Breast Cancer Bone Metastases. Hum. Gene Ther. 26:813-825. 2015. PMID:26467629

16. Bi, X., Xia, X., Fan, D., Mu, T., Zhang, Q., Iozzo, R.V., Yang, W. Oncogenic activin C interacts with decorin in colorectal cancer in vivo and in vitro. Mol. Carcinog. 55:1786-1795. 2016. PMID:26509701

17. Poluzzi C., Iozzo, R.V., Schaefer, L. Endostatin and endorepellin: A common route of action for similiar angiostatic cancer avengers. Adv. Drug Deliv. Rev. 97:156-173. 2016. PMID:26518982

18. Neill, T., Schaefer, L., Iozzo, R.V. Decorin as a multivalant therapeutic agent against cancer. Adv. Drug Deliv. Rev. 97:174-185. 2016. PMID:26522384

19. Hsieh, L.T., Frey, H., Nastase, M.V., Tredup, C., Hoffman, A., Poluzzi, C., Zeng-Brouwers, J., Schroeder, K., Brandes, R.P., Iozzo, R.V., Schaefer, L. Bimodal role of NADPH oxidases in the regulation of biglycan-triggered IL-1 synthesis. Matrix Biol. 49:61-81. 2016. PMID:26689330

20. Klionsky, D.J., et al. Guidelines for the use and interpretation of assay for monitoring autophagy (3rd edition). Autophagy. 12:1-222. 2016. PMID:26799652

21. Nastase, M.V., Zeng-Brouwers, J., Frey, H., Hsieh, L.T., Poluzzi, C., Beckmann, J., Schroeder, N., Pfeilschifter, J., Lopez-Mosqueda, J., Mersmann, J., Ikeda, F., Iozzo, R.V., Dikic, I., Schaefer, L. An essential role for SHARPIN in the regulation of caspase 1 activity in sepsis. Am. J. Pathol. 186:1206-1220. 2016. PMID:26968342

22. Buraschi, S., Xu, S.Q., Stefanello, M., Moskalev, I., Morcavallo, A., Genua, M., Tanimoto, R., Birbe, R., Peiper, S.C., Gomella, L.G., Belfiore, A., Black, P.C., Iozzo, R.V.*, and Morrione, A. Suppression of progranulin expression inhibits bladder cancer growth and sensitizes cancer cells to cisplatin. Oncotarget. 7:39980-39996. 2016. PMID: 27220888

23. Gronau, T., Kruger, K., Prein, C., Aszodi, A., Gronau, I., Iozzo, R.V., Mooren, F.C., Clausen-Schaumann, H., Bertrand, J., Pap, T., Bruckner, P., and Dreier, R. Force exercise-induced osteoarthritis is attenuated in mice lacking the small leucine-rich proteoglycan decorin. Ann. Rheum. Dis. 76:442-449. 2017. PMID:27377816

24. Goyal, A., Gubbiotti, M.A., Chery, D.R., Han, L., and Iozzo, R.V. Endorepellin-evoked autophagy contributes to angiostasis. J. Biol. Chem. 291:19245-19256. 2016. PMID:27435676

25. Lu, H., Wang, T., Li, J., Fedele, C., Liu, Q., Zhang, J., Jiang, Z., Jain, D., Iozzo, R.V., Violette, S.M., Weinreb, P.H., Davis, R.J., Gioeli, D., FitzGerald, T.J., Altieri, D.C., and Languino, L.R. v6 integrin promotes castrate-resistant prostate cancer through JNK1-mediated activation of androgen receptor. Cancer Res. 76:5163-5174. 2016. PMID:27450452

26. Tanimoto, R., Lu, K.G., Xu, S.Q., Buraschi, S.B., Belfiore, A., Iozzo, R.V., and Morrione, A. Mechanisms of progranulin action and regulation in genitourinary cancers. Front. Endocrinol. 7:100. 2016. PMID:27512385

27. Barallobre-Barreiro, J., Gupta, S.K., Zoccarato, A., Kitazume-Taneike, R., Fava, M., Yin, X., Werner, T., Hirt, M.N., Zampetaki, A., Viviano, A., Chong, M., Bern, M., Kourliouros, A., Domenech, N., Willeit, P., Shah, A.M., Jahangiri, M., Schaefer, L., Fischer, J.W., Iozzo, R.V., Viner, R., Thum, T., Heineke, J., Kichler, A., Otsu, K., and Mayr, M. Glycoproteomics reveals decorin peptides with anti-myostatin activity in human atrial fibrillation. Circulation. 134:817-832. 2016. PMID:2755

28. Gubbiotti, M.A., Vallet, S.D., Ricard-Blum, S., and Iozzo, R.V. Decorin interacting network: A comprehensive analysis of decorin-binding partners and their versatile functions. Matrix Biol. 55:7-21. 2016. PMID:27693454

29. Buraschi S., Xu, S.Q., Stefanello, M., Moskalev, I., Morcavallo, A., Genua, M., Tanimoto, R., Birbe, R., Peiper, S.C., Gomella, L.G., Belfiore, A., Black, P.C., Iozzo, R.V., and Morrione, A. Suppression of progranulin expression inhibits bladder cancer growth and sensitizes cancer cells to cisplatin. Oncotarget. 7:39980-39995. 2016. PMID:27220888

30. DeRita, R.M., Zerlanko, B., Singh, A., Lu, H., Iozzo, R.V., Benovic, J.L., and Languino, L.R. c-Src insulin-like growth factor I receptor, G-protein-coupled receptor kinases and focal adhesion kinase are enriched into prostate cancer cell exosomes. J. Cell. Biochem. 118:66-73. 2017. PMID: 27232975

31. Schaefer, L., Tredup, C., Gubbiotti, M.A., and Iozzo, R.V. Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology. FEBS J. 284:10-26. 2017. PMID:27860287

32. Neill, T., Buraschi, S., Goyal, A., Sharpe, C., Natkanski, E., Schaefer, L., Morrione, A., and Iozzo, R.V. EphA2 is a functional receptor for the growth factor progranulin. J. Cell Biol. 215:687-703. 2016. PMID:27903606

33. Pozzi, A., Yurchenco,P.D., and Iozzo, R.V. The nature and biology of basement membranes. Matrix Biol. 57-58:1-11. 2017. PMID:28040522

34. Gubbiotti, M.A., Neill, T., and Iozzo, R.V. A current view of perlecan in physiology and pathology: A mosaic of functions. Matrix Biol. 57-58:285-298. 2017. PMID:27613501

35. Frey, H., Moreth, K., Hsieh, L.T., Zeng-Brouwers, J., Rathkolb, B., Fuchs, H., Gailus-Durner, V., Iozzo, R.V., de Angelis, M.H., and Schaefer, L. A novel biological function of soluble biglycan: induction of erythropoietin production and polycythemia. Glycoconj. J 34:393-404, 2017. PMID:27600268

36. Torres, A., Gubbiotti, M., and Iozzo, R.V. Decorin-inducible Peg3 evokes Beclin 1-mediated autophagy and thrombospondin 1-mediated angiostasis. J. Biol. Chem. 292:5055-5069. 2017. PMID:28174297

37. Neill, T., Sharpe, C., Owens, R.T., Iozzo, R.V. Decorin-evoked Paternally Expressed Gene 3 (PEG3) is an upstream regulator of the Transcription Factor EB (TFEB) in endothelial cell autophagy. J. Biol. Chem. 292:16211-16220. 2017 PMID:28798237

38. Tanimoto, R., Palladino, C., Xu, S.Q., Buraschi, S., Neill, T., Gomella, L.G., Peiper, S.C., Belfiore, A., Iozzo, R.V., and Morrione, A. The perlecan-interacting growth factor progranulin regulates ubiquitination, sorting, and lysosomal degradation of sortilin. Matrix Biol. 64:27-39. 2018. PMID:28433812

39. Andreuzzi, E., Colladel, R., Pellicani, R., Tarticchio, G., Cannizzaro, R., Spessotto, P., Bussolati, B., Brossa, A., De Paoli, P., Canzonieri V., Iozzo, R.V., Colombatti, A., and Mongiat, M. The angiostatic molecule Multimerin 2 is processed by MMP-9 to allow sprouting angiogenesis. Matrix Biol. 64:40-53, 2018. PMID:28435016

40. Galvagni, F., Nardia, F., Spiga, O., Trezza, A., Tarticchio, G., Pellicani, R., Andreuzzi, E., Caldi, E., Toti, P., Tosi, G.M., Santucci, A., Iozzo, R.V., Mongiat, M., Orlandini, M.. Dissecting the CD93-Multimerin 2 interaction involved in cell adhesion and migration of the activated endothelium. Matrix Biol. 64:112-127, 2018.

41. Montano, M., Dinnon, K.H., Jacobs.,L., Xiang.,W., Iozzo, R.V., Bushman, W., Dual regulation of decorin by androgen and hedgehog signaling during prostate morphogenesis. Dev. Dyn. 247:679-685. 2018. PMID:29368411

42. Iozzo R.V., Gubbiotti M.A. Extracellular matrix: The driving force of mammalian diseases. Matrix Biol. 71-72:1-9. 2018. PMID:29625183

43. Lin R, Lang M, Heinsinger N, Stricsek G, Zhang J, Iozzo R.V., Rosenwasser R, Iacovitti L. Stepwise impairment of neural stem cell proliferation and neurogenesis concomitant with disruption of blood-brain barrier in recurrent ischemic stroke. Neurobiol. Dis. 115:49-58, 2018. PMID:29605425

44. Neill T., Andreuzzi, E., Wang,Zi-Xuan, Peiper,S.C., Mongiat,M., Iozzo,R.V. Endorepellin remodels the endothelial transcriptome toward a pro-autophagic and pro-mitophagic gene signature. J. Biol. Chem. 293:12137-12148, 2018. PMID: 29921586

45. Xu, S.Q., Buraschi, S., Tanimoto, R., Stefanello, M., Belfiore, A., Iozzo, R.V., Morrione, A. Analysis of progranulin-mediated Akt and MAPK activation. Methods Mol. Biol. 1806:121-130, 2018. PMID: 29956273

46. Gubbiotti, M.A., Seifert, E.L., Hoek, J.B., Iozzo, R.V. Metabolic reprogramming of murine cardiomyocytes during autophagy requires the extracellular nutrient sensor, decorin. J. Biol. Chem. 293:16940-16950, 2018. PMID:30049794

47. Bouris P. , Manou D. , Sopaki-Valalaki A., Kolokotroni A., Moustakas A., Kapoor A., Iozzo R.V., Karamanos N.K., Theocharis A.D. Serglycin promotes breast cancer cell aggressiveness: Induction of epithelial to mesenchymal transition, proteolytic activity and IL-8 signaling. Matrix Biol. 74:35-5, 2018. PMID:29842969

48. Karamanos, N.K., Piperigkou, Z., Theocharis, A.D., Watanabe, H., Franchi, M., Baud, S., Brezillon, S., Gotte, M., Passi, A., Vigetti, D., Ricard-Blum, S., Sanderson, R.D., Neill, T., Iozzo R.V. Proteoglycan chemical diversity drives multifunctional cell regulation and therapeutics. Chem. Rev. 118:9152-9232, 2018. PMID: 30204432

49. Buraschi, S., Neill, T., Iozzo, R.V., Decorin is a devouring proteoglycan: Remodeling of intracellular catabolism via autophagy and mitophagy. Matrix Biol. 75-76:260-270, 2019. PMID: 29080840

50. Karamanos, N.K., Theocharis, A.D., Neill, T., Iozzo, R.V. Matrix modeling and remodeling: A biological interplay regulating tissue homeostasis and diseases. Matrix Biol. 75-76:118-138, 2019. PMID:30130584

51. Karalis T.T., Heldin P., Vynios D.H., Neill T., Buraschi S., Iozzo R.V., Karamanos N.K., Skandalis S.S. Tumor-suppressive functions of 4-MU on breast cancer cells of different ER status: Regulation of hyaluronan/HAS2/CD44 and specific matrix effectors. Matrix Biol. 78-79:1-11, 2019. PMID:29673760

52. Krishn, S.R., Singh, A., Bowler, N., Duffy, A.N., Friedman, A., Fedele, C., Kurtoglu, S., Tripathi, S.K., Wang, K., Hawkins, A., Sayeed, A., Goswami, C.P., Thakur, M.L., Iozzo, R.V., Peiper, S.C., Kelly, W.K., Languino, L.R. Prostate cancer sheds the v3 integrin in vivo through exosomes. Matrix Biol. 77:41-57, 2019. PMID:30098419

53. Lin R, Cai J, Kenyon L, Iozzo R.V., Rosenwasser R, Iacovitti L. Systemic factors trigger vasculature cells to drive Notch signaling and neurogenesis in neural stem cells in the adult brain. Stem Cells 37:395-406, 2019. PMID:30431198

54. Poluzzi C., Nastase M.V., Zeng-Brouwers J., Roedig H., Hsieh L.T., Michaelis J.B., Buhl E.M., Rezende F., Manavski Y., Bleich A., Boor P., Brandes R.P., Pfeilschifter J., Stelzer E.H.K., Münch C., Dikic I., Brandts C., Iozzo R.V., Wygrecka M., Schaefer L. Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury. Kidney Int. 95:540-562, 2019. PMID: 30712922

55. Chen C., Kapoor A., Iozzo R.V. Methods for monitoring matrix-induced autophagy. Methods Mol. Biol. 1952:157-191, 2019. PMID: 30825174

56. Passi A., Vigetti D., Buraschi S., Iozzo R.V. Dissecting the role of hyaluronan synthases in the tumor microenvironment. FEBS J. 286: 2937-2949, 2019. PMID: 30974514

57. Campbell K.R, Chaudhary R., Montano M., Iozzo R.V., Bushman WA, Campagnola P.J. Second-harmonic generation microscopy analysis reveals proteoglycan decorin is necessary for proper collagen organization in prostate. J Biomed Opt. 24(6):1-8, 2019 PMID:31148435

58. Mongiat M, Buraschi S., Andreuzzi E., Neill T., Iozzo, R.V. Extracellular matrix: the gatekeeper of tumor angiogenesis. Biochem. Soc. Trans. 47(5):1543-1555, 2019. PMID:31652436

59. Han B., Li Q., Wang C., Patel P., Adams S.M., Doyran B., Nia H.T., Oftadeh R., Zhou S., Li C.Y., Liu X.S., Lu X.L., Enomoto-Iwamoto M., Qin L., Mauck R.L., Iozzo RV, Birk D., Han L. Decorin regulates the aggrecan network integrity and biomechanical functions of cartilage extracellular matrix. ACS Nano. 13(10): 11320-11333, 2019 PMID: 31550133

60. Pellicani R., Poletto E., Andreuzzi E., Paulitti A., Doliana R., Bizzotto D., Braghetta P., Colladel R., Tarticchio G., Sabatelli P., Bucciotti F., Bressan G., Iozzo R.V., Colombatti A., Bonaldo P., Mongiat M. Multimerin-2 maintains vascular stability and permeability. Matrix. Biol. 87:11-25 2020. PMID:31422156

61. Gubbiotti M.A., Buraschi S., Kapoor A., Iozzo R.V. Proteoglycan signaling in tumor angiogenesis and endothelial cell autophagy. Semin. Cancer Biol. 62:1-8 2020. PMID:31078640

62. Buraschi S., Morcavallo A., Neill T., Stefanello, M., Palladino C., Xu S-Q., Belfiore A., Iozzo, R.V*., Morrione A. Discoidin Domain Receptor 1 functionally interacts with the IGF-I system in bladder cancer. Matrix Biol Plus In Press 2020

63. Kapoor A., Chen C.G, Iozzo, R.V. A simplified aortic ring assay: A useful ex vivo method to assess biochemical and functional parameters of angiogenesis. Matrix Biol Plus In Press 2020

64. Chen C.G., Gubbiotti M.A., Kapoor A., Han X., Yu Y., Linhardt R.J., Iozzo RV. Autophagic degradation of HAS2 in endothelial cells: A novel mechanism to regulate angiogenesis. Matrix Biol In Press 2020 PMID: 32084457

65. Li Q., Han B., Wang C., Tong W., Wei Y., Tseng W.J., Han L.H., Liu X.S., Enomoto-Iwamoto M., Mauck R.L., Qin L., Iozzo R.V., Birk D.E., Han L. Decorin mediates cartilage matrix degeneration in post-traumatic osteoarthritis. Arthritis Rheumatol. 2020 Mar 12. doi: 10.1002/art.41254. Online ahead of print. PMID: 32162789

66. Neill T., Chen C.G., Buraschi S., Iozzo,R.V. Catabolic degradation of endothelial VEGFA via autophagy. J. Biol. Chem. 295(18):6064-6079, 2020 PMID: 32209654

67. Kapoor A., Chen C.G, Iozzo, R.V. Endorepellin evokes an angiostatic stress signaling cascade in endothelila cells. J. Biol. Chem. 295(19):6344-6356. 2020 PMID: 32205445


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